jmc

We first place the non-math books. There are $4$ choices for the first book, $3$ choices for the second book, $2$ choices for the third book, and $1$ choice for the last book. Then we have to put the two math books between the four non-math books such that there is at least one non-math book between the two math books. We see there is a total of $5$ openings created by the four non-math books. So the first math book has $5$ choices, and the second math book has $4$ choices.

So the total number of ways the books can be placed is $4\times 3\times 2\times 1\times 5\times 4=\boxed{480}.$