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$221$ can be written as the sum of four two-digit numbers, let's say $\overline{ae}$, $\overline{bf}$, $\overline{cg}$, and $\overline{dh}$. Then $221=10(a+b+c+d)+(e+f+g+h)$. The last digit of $221$ is $1$, and $10(a+b+c+d)$ won't affect the units digits, so $(e+f+g+h)$ must end with $1$. The smallest value $(e+f+g+h)$ can have is $(1+2+3+4)=10$, and the greatest value is $(6+7+8+9)=30$. Therefore, $(e+f+g+h)$ must equal $11$ or $21$. Case 1: $(e+f+g+h)=11$ The only distinct positive integers that can add up to $11$ is $(1+2+3+5)$. So, $a$,$b$,$c$, and $d$ must include four of the five numbers $(4,6,7,8,9)$. We have $10(a+b+c+d)=221-11=210$, or $a+b+c+d=21$. We can add all of $4+6+7+8+9=34$, and try subtracting one number to get to $21$, but none of them work. Therefore, $(e+f+g+h)$ cannot add up to $11$. Case 2: $(e+f+g+h)=21$ Checking all the values for $e$,$f$,$g$,and $h$ each individually may be time-consuming, instead of only having $1$ solution like Case 1. We can try a different approach by looking at $(a+b+c+d)$ first. If $(e+f+g+h)=21$, $10(a+b+c+d)=221-21=200$, or $(a+b+c+d)=20$. That means $(a+b+c+d)+(e+f+g+h)=21+20=41$. We know $(1+2+3+4+5+6+7+8+9)=45$, so the missing digit is $45-41=\boxed{4}$